The hospital has 731 beds and 61 bassinets and maintains a steady occupancy rate close to 100%. It offers the most advanced care in all medical disciplines, including open-heart surgery for both adults and children.

The hospital also excels in intensive care for medical, surgical, newborn, and pediatric patients. The Don Monti Cancer Center has a full-service bone marrow transplant unit. The institution is a designated Level 1 Trauma Center.

The North Shore-Long Island Jewish Health Systems strives to improve the health of the communitites it serves and is committed to providing the highest quality clinical care; educating the current and future generations of health care professionals; searching for new advances in medicine through the conduct of bio-medical research; promoting health education; and caring for the entire community regardless of the ability to pay.

In 2002, North Shore University Hospital at Manhasset ranked as the top hospital in America by AARP Modern Maturity and the top hospital on Long Island by Newsday.

In addition, the health system is the recipient of the Codman Award from the Joint Commission on Accreditation of Healthcare Organizations (JCAHO), the first health system to attain this distinction.